Publications
2019
N. Moriarty, C.L. Parish, E. Dowd. Primary tissue for cellular brain repair in Parkinson's disease: Promise, problems and the potential of biomaterials. Eur J Neurosci. Review. (2019), Feb, 49(4), 472-486.
2018
K. Bruggeman, N. Moriarty, E. Dowd, D.R. Nisbet, C.L Parish. Harnessing stem cells and biomaterials for neural repair. British Journal of Pharmacology Review, (2018), Nov 16, 355-368.
D.R. Nisbet, T.Y. Wang, K.F. Bruggemann, F. Somma, J.C. Niclis, L.H. Thompson, C.L. Parish. Shear containment of BDNF within molecular hydrogels promote human stem cell engraftment and post-infarction remodeling in stroke. Advanced Biosystems, (2018), July 18, 2(9).
Ermine CM, Wright JL, Frausin S, Kauhausen JA, Parish CL, Stanic D, Thompson LH (2018), Modelling the dopamine and noradrenergic cell loss that occurs in Parkinson's disease and the impact on hippocampal neurogenesis, Hippocampus (2018), May; 28(5), 327-337.
A.L. Rodriguez, K.F. Bruggeman, T.Y. Wang, R.J. Williams, C.L. Parish* and D.R. Nisbet*. Using minimalist self-assembling peptides as hierarchial scaffolds to stabilize growth factors and promote stem cell graft integration in the injured brain. Journal of Tissue Engineering and Regenerative Medicine (2018) Mar, 12(3), e1571-e1579. *equal contribution
K. Bruggeman, Y. Wang, F. Maclean, C.L Parish, R. Williams, D. Nisbet. Temporally Controlled Growth Factor Delivery from a Self-Assembling Peptide Hydrogel and Electrospun Nanofibre Composite Scaffold. Nanoscale (2017), Sep 21, 9(36), 13661-13669.
W.F. Alsanie, J.C. Niclis, C.P. Hunt, I.R. De Luzy, V. Penna, C.R. Bye, C.W. Pouton, J. Haynes, J. Firas, L.H. Thompson, C.L. Parish. Specification of murine ground state pluripotent stem cells to regional neuronal populations. Scientific Reports (2017), Nov 22; 7(1), 16001.
2017
W.F. Alsanie, V. Penna, M. Schachner, L.H. Thompson, C.L. Parish. Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways. Scientific Reports (2017), Aug 24;7(1):9368
J.C. Niclis, C.W. Gantner, J.A. Kauhausen, J. Durnall, C. Hunt, C.W. Pouton, J. Haynes, C.L Parish*, L.H Thompson* A human Pitx3-GFP embryonic stem cell line reveals the extent and pattern of growth for dopamine and non-dopamine neuronal subtypes following intra-striatal transplantation. Stem Cell Reports (2017), Sep 12; 9(3): 868–882 *equal contribution
Somaa, F.A., Wang, T.-Y., Niclis, J.C., Bruggeman, K.F., Kauhausen, J.A., Guo, H., McDougall, S., Williams, R.J., Nisbet, D.R., Thompson, L.H., and Parish, C.L. Peptide-based scaffolds support human pluripotent stem cell-derived neuronal graft integration, neuroprotection and long term functional recovery in a rodent model of stroke. Cell Reports (2017), Aug 22; 20(8), 1964-1977.
J.C. Niclis, C Turner, J.Durnall, S. McDougall, J.A. Kauhausen, B. Leaw, M. Dottori, C.L. Parish, L.H. Thompson. Long-distance axonal growth and protracted functional maturation of neurons derived from human induced pluripotent stem cells after intra-cerebral transplantation. Stem Cells Translational Medicine (2017), Jun 6; (6):1547-1556.
JC. Niclis, CW. Gantner, WF. Alsanie, SJ. McDougall, CR. Bye, AG. Elefanty, EG. Stanley, JM. Haynes, CW. Pouton, LH. Thompson, CL. Parish. Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno‐Free Conditions Restore Motor Deficits in Parkinsonian Rodents. Stem Cells Translational Medicine (2017) Mar 6; (3):937-948.
2016
Kao T, Labonne T, Niclis JC, Chaurasia R, Lokmic Z, Qian E, Bruveris FF, Howden SE, Motazedian A, Schiesser JV, Costa M, Sourris K, Ng E, Anderson D, Giudice A, Farlie P, Cheung M, Lamande SR, Penington AJ, Parish CL, Thomson LH, Rafii A, Elliott DA, Elefanty AG, Stanley EG (2016), GAPTrap: a Simple Expression System for Pluripotent Stem Cells and their Derivatives. Stem Cell Reports, vol. 7, pg. 518-526.
Wright JW, Ermine CM, Jorgensen JR, Parish CL, Thompson LH (2016). Over-expression of Meteorin drives gliogenesis following striatal injury. Front Cell Neuro, vol. 10, pg. 177.
Ermine CM, Wright JL, Parish CL, Stanic D, Thompson LH. Combined immunohistochemical and retrograde tracing reveals little evidence for innervation of the rat dentate gyrus from midbrain dopamine neurons. Frontiers in Biology. In Press.
2015
Kauhausen JA, Thompson LH, Parish CL (2015), Chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in Parkinsonian mice. Mol Cell Neurosci, vol. 69, pg. 22-9,
Bye C, Jonsson M, Bjorklund A, Parish P, Thompson LH (2015), Transcriptome analysis identifies transmembrane targets on midbrain dopamine progenitors, PNAS, In Press
Somaa F, Bye C, Thompson LH, Parish C (2015), Meningeal cells influence midbrain development and the engraftment of dopamine progenitors in Parkinsonian mice, Exp Neurol, In Press
2014
Bird M, Needham K, Frazier AE, van Rooijen J, Leung J, Hough S, Denham M, Thornton ME, Parish CL, Nayagam B, Pera M, Thornburn DR, Thompson LH, Dottori M (2014), Functional characterization of Friedreich Ataxia iPS-derived neuronal progenitors and their integration in the adult brain, PLoS One, in press.
Hall H, Reyes S, Landeck N, Bye C, Leanza G, Double K, Thompson L, Halliday G, Kirik D (2014), Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson’s disease, Brain, in press.
Sahin G, Thompson LH, Lavisse S, Ozgur M, Carta M, Rbah L, Dolle F, Hantraye P, Kirik D (2014), Differential dopamine receptor occupancy underlies L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease, PLoS One, in press.
2013
Wright J, Stanic S, Thompson LH (2013), Generation of striatal projection neurons extends into the neonatal period in the rat brain. J Physiol, vol. 591(Pt 1), pg. 67-76.
Kauhausen J, Thompson LH, Parish CL (2013), Cell intrinsic and extrinsic factors contribute to enhance neural circuit reconstruction following transplantation in Parkinsonian mice. J Physiol, vol. 591(Pt 1), pg. 77-91.
Reyes S, Fu Y, Double KL, Cottam V, Thompson L, Kirik D, Paxinos G, Watson C, Cooper HM, Halliday GM (2013), Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease. Neurobiol Aging, vol. 34(3), pg. 873-86.
2012
Denham M, Bye C, Leung J, Conley B, Thompson LH, Pera M, Dottori M (2012), GSK3β and Activin/Nodal Inhibition in Human Embryonic Stem Cells induces a Pre-neuroepithelial State that is required for Specification to a Floor Plate Cell Lineage, Stem Cells, vol. 30(11), pg. 3400-11.
Bye CR, Thompson LH and Parish CL (2012), Birth dating of midbrain dopamine neurons identifies A9 enriched tissue for transplantation into Parkinsonian mice, Exp Neurol, vol. 236(1), pg. 58-68.
Denham M, Parish CL, Leaw B, Wright J, Reid CA, Petrou S, Dottori M and Thompson LH (2012), Neurons derived from human embryonic stem cells extend long–distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation, Front Neurosci
Reyes S, Fu Y, Double K, Thompson L, Kirik D, Paxinos G, and Halliday GM (2012), GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area, J Comp Neurol, vol. 520(12), pg. 2591-607.
Jørgensen JR, Fransson A, Fjord-Larsen L, Thompson LH, Houchins JP, Andrade N, Torp M, Kalkkinen N, Andersson E, Lindvall O, Ulfendahl M, Brunak S, Johansen TE, Wahlberg LU (2012), Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo, Exp Neurol, vol. 233(1), pg. 72-81
2011
Jorgensen JR, Emerich DF, Thompson LH, Torp M, Bintz B, Fjord-Larsen L, Johansen T, Wahlberg LU (2011), Lentiviral delivery of Meteorin protects striatal neurons against excitotoxicity and reverses motor deficits in the quinolinic acid rat model, Neurobiol Dis, vol. 41(1), pg. 160-8.
2010
Denham M, Thompson LH, Leung J, Pebay A, Bjorklund A, Dottori M (2010), Gli1 is an Inducing Factor in Generating Floorplate Progenitor Cells from Human Embryonic Stem Cells, Stem Cells, vol. 28(10), pg. 1805-15.
Grealish S, Jonsson M, Li M, Kirik D, Bjorklund A, Thompson LH (2010), Midbrain Dopamine Neuronal Subtype Composition in Intra-striatal Grafts of Ventral Mesencephalon is an Important Determinant of Functional Efficacy, Brain, vol. 133(2), pg. 482-95.
2009
Thompson LH, Grealish S, Kirik D, Bjorklund A (2009), Reconstruction of the Nigro-striatal Dopamine Pathway in the Adult Mouse Brain, Eur J Neurosci, vol. 30(4), no. 625-38.
Jonsson ME, Ono Y, Bjorklund A, Thompson LH (2009), Identification of Transplantable Dopamine Neuron Precursors at Different Stages of Midbrain Neurogenesis, Exp Neurol, vol. 219(1), pg. 341-54.
Jørgensen JR, Thompson L, Fjord-Larsen L, Krabbe C, Torp M, Kalkkinen N, Hansen C, Wahlberg L (2009), Characterization of Meteorin-An Evolutionary Conserved Neurotrophic Factor, J Mol Neurosci, vol. 39(1-2), pg. 104-16.
Friling S, Andersson E, Thompson LH, Jönsson ME, Hebsgaard JB, Nanou E, Alekseenko Z, Marklund U, Kjellander S, Volakakis N, Hovatta O, El Manira A, Björklund A, Perlmann T, Ericson J (2009), Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells, PNAS, vol. 106(18), pg. 7613-8
2008
Thompson LH, Kirik D, Bjorklund A (2008), Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain, Exp Neurol, vol. 213(1), pg. 220-8.
Irvin DK, Kirik D, Bjorklund A, Thompson LH (2008), In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway, Neurobiol Dis, vol. 30(3), pg. 343-52.
2006
Thompson L*, Andersson E*, Jensen J, Barraud P, Guillemot F, Parmar M, Bjorklund A (2006), Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon, Exp Neurol, vol. 198(1), pg. 183-98.
2005
Barraud P#, Thompson L#, Kirik D, Bjorklund A, Parmar M, (2005), In vitro and in vivo properties of Sox1-GFP cells isolated from foetal brain, adult brain or expanded neurosphere culture, Eur J Neurosci, vol. 22(7), pg. 1555-69.
Thompson L, Barraud P, Andersson E, Kirik D, Bjorklund A (2005), Identification of dopaminergic neurons of nigral and VTA subtypes in grafts of foetal ventral mesencephalon based on cell morphology, protein expression and efferent projections, J Neurosci, vol. 25(27), pg. 6467-77.
Toft Sørensen A, Thompson L, Kirik D, Björklund A, Lindvall O, Kokaia M (2005), Functional properties and synaptic integration of genetically labeled dopaminergic neurons in intrastriatal grafts, Eur J Neurosci, vol. 21(10), pg. 2793-9.
Navarro-Galve B, Villa A, Bueno C, Thompson L, Johansen J, Martinez-Serrano A (2005), Gene marking of human neural stem/precursor cells using green fluorescent proteins, J Gene Med, vol. 7(1), pg. 18-29.
2004
Jakobsson J, Rosenqvist N, Thompson L, Barraud P, Lundberg C (2004), Dynamics of transgene expression in a neural stem cell line transduced with lentiviral vectors incorporating the cHS4 insulator, Exp Cell Res, vol. 298(2), pg. 611-23.